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Abstract #1953

Using the ADNI1 data set to assess the back-to-back reproducibility of brain volumetrics

Keith S Cover 1 , Ronald A van Schijndel 1 , Adriaan Versteeg 1 , Alberto Redolfi 2 , Jrme Revillard 3 , Baptiste Grenier 3 , David Manset 3 , Hugo Vrenken 1 , Bob W van Dijk 1 , Giovanni B Frisoni 2 , and Frederik Barkhof 1

1 VU University Medical Center, Amsterdam, Netherlands, 2 IRCCS San Giovanni di Dio Fatebenefratelli, Italy, 3 gnbila France, France

To compare the reproducibility of the hippocampal atrophy rates over one year generated by different versions of the FreeSurfer/ReconAll and FSL/FIRST software packages using a back-to-back (BTB) reproducibility test. The test is based on the first Alzheimer's Disease Neuroimaging Initiative (ADNI1) data set - which includes two MPRAGE scans for each patient visit. The FSL/FIRST and FreeSurfer/ReconAll reproducibilities of hippocampal atrophy rates were similar. The poor reproducibility of the well documented bug in longitudinal mode of FreeSurfer 5.0.0 is clearly evident. The ADNI1-based BTB benchmark presented is a valuable way to compare performance of volumetric algorithms.

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