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Abstract #1934

Cortical Phase Shifts in Subjective Cognitive Impairment at 7 Tesla

Mathijs Buijs 1 , Sanneke van Rooden 1 , Maarten Versluis 1 , Andrew Webb 1 , Mark van Buchem 1 , and Jeroen van der Grond 1

1 Radiology, Leiden University Medical Center, Leiden, Netherlands

Subjective cognitive impairment can be prodromal to Alzheimer's disease. Alzheimer-related pathology has been known to precede symptoms by as much as two decades. Using 7 Tesla MRI, cortical Alzheimer-related phase shifts can be visualized. We investigated whether these phase shifts could be detected in SCI, and whether there is a correlation between phase shifts and cognitive performance. We found significant correlations between measured cortical phase shifts and neuropsychological test scores. In subjects with SCI no AD-like phase shifts could be determined.

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