Cortical Phase Shifts in Subjective Cognitive Impairment at 7 Tesla
Mathijs Buijs 1 , Sanneke van Rooden 1 , Maarten Versluis 1 , Andrew Webb 1 , Mark van Buchem 1 , and Jeroen van der Grond 1
Radiology, Leiden University Medical Center,
Subjective cognitive impairment can be prodromal to
Alzheimer's disease. Alzheimer-related pathology has
been known to precede symptoms by as much as two
decades. Using 7 Tesla MRI, cortical Alzheimer-related
phase shifts can be visualized. We investigated whether
these phase shifts could be detected in SCI, and whether
there is a correlation between phase shifts and
cognitive performance. We found significant correlations
between measured cortical phase shifts and
neuropsychological test scores. In subjects with SCI no
AD-like phase shifts could be determined.
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