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Abstract #1927

Structural, Metabolic and Functional Relationships between the Eye and the Brain in Glaucoma using Multimodal MRI and Optical Coherence Tomography

Matthew C. Murphy 1,2 , Ian P. Conner 1 , Seong-Gi Kim 2,3 , Gadi Wollstein 1 , Joel S. Schuman 1 , and Kevin C. Chan 1,2

1 Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, United States, 2 Neuroimaging Laboratory, Department of Radiology, University of Pittsburgh, Pittsburgh, PA, United States, 3 Center for Neuroscience Imaging Research, Department of Biological Sciences, SKKU, Suwon, Korea

Glaucoma is a neurodegenerative disease that affects the entire visual system, from eye to visual cortex. However, the pathogenesis of glaucoma in the human visual brain and its relationship with progression in the eye remains largely unknown. The purpose of this study was to assess that relationship in a group of 22 subjects spanning the spectrum of glaucoma severity. The results indicate a significant relationship between disease severity (as assessed by both clinical diagnosis and ocular structural measurements) and measures of brain function (measured by BOLD response to visual stimulation) and metabolism (measured by proton MRS in the visual cortex).

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