Abstract #1927
Structural, Metabolic and Functional Relationships between the Eye and the Brain in Glaucoma using Multimodal MRI and Optical Coherence Tomography
Matthew C. Murphy 1,2 , Ian P. Conner 1 , Seong-Gi Kim 2,3 , Gadi Wollstein 1 , Joel S. Schuman 1 , and Kevin C. Chan 1,2
1
Department of Ophthalmology, University of
Pittsburgh, Pittsburgh, PA, United States,
2
Neuroimaging
Laboratory, Department of Radiology, University of
Pittsburgh, Pittsburgh, PA, United States,
3
Center
for Neuroscience Imaging Research, Department of
Biological Sciences, SKKU, Suwon, Korea
Glaucoma is a neurodegenerative disease that affects the
entire visual system, from eye to visual cortex.
However, the pathogenesis of glaucoma in the human
visual brain and its relationship with progression in
the eye remains largely unknown. The purpose of this
study was to assess that relationship in a group of 22
subjects spanning the spectrum of glaucoma severity. The
results indicate a significant relationship between
disease severity (as assessed by both clinical diagnosis
and ocular structural measurements) and measures of
brain function (measured by BOLD response to visual
stimulation) and metabolism (measured by proton MRS in
the visual cortex).
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