Abstract #1919
Improved microstructural characterisation of T2-hyperintense lesions by combining multi-shell diffusion MRI and myelin water imaging
Thibo Billiet 1,2 , Sabine Deprez 1,2 , Burkhard Maedler 3 , Felice D'Arco 4 , Ellen Plasschaert 5 , Ronald Peeters 1,2 , Hui Zhang 6 , Alexander Leemans 7 , Bea Van den Bergh 8 , Mathieu Vandenbulcke 9 , Eric Legius 5 , Stefan Sunaert 1,2 , and Louise Emsell 1,2
1
Translational MRI, Imaging & Pathology, KU
Leuven & Radiology, University Hospitals Leuven, Leuven,
Belgium,
2
Medical
Imaging Research Center, Leuven, Belgium,
3
Stereotaxis
and MR-based Intervention, Department of Neurosurgery,
Bonn University Hospital, Bonn, Germany,
4
Diagnostic
Imaging and Radiotherapy, University Federico II of
Naples, Salerno, Italy,
5
Human
Genetics, KU Leuven & University Hospitals Leuven,
Leuven, Belgium,
6
Computer
Science, University College London, London, United
Kingdom,
7
University
Medical Center, Utrecht, Netherlands,
8
Developmental
Psychology, Tilburg University, Tilburg, Netherlands,
9
Psychiatry,
KU Leuven & University Hospitals Leuven, Leuven, Belgium
Often Neurofibromatosis type 1 (NF1) patients express
hyperintensities on T2-weighted MRI brain scans. Their
microstructure is still not well understood. Combining
multicomponent T2 relaxation and advanced diffusion
techniques (DTI, DKI, NODDI) we try to characterize
these so-called "unidentified bright objects" (UBOs)
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