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Abstract #1919

Improved microstructural characterisation of T2-hyperintense lesions by combining multi-shell diffusion MRI and myelin water imaging

Thibo Billiet 1,2 , Sabine Deprez 1,2 , Burkhard Maedler 3 , Felice D'Arco 4 , Ellen Plasschaert 5 , Ronald Peeters 1,2 , Hui Zhang 6 , Alexander Leemans 7 , Bea Van den Bergh 8 , Mathieu Vandenbulcke 9 , Eric Legius 5 , Stefan Sunaert 1,2 , and Louise Emsell 1,2

1 Translational MRI, Imaging & Pathology, KU Leuven & Radiology, University Hospitals Leuven, Leuven, Belgium, 2 Medical Imaging Research Center, Leuven, Belgium, 3 Stereotaxis and MR-based Intervention, Department of Neurosurgery, Bonn University Hospital, Bonn, Germany, 4 Diagnostic Imaging and Radiotherapy, University Federico II of Naples, Salerno, Italy, 5 Human Genetics, KU Leuven & University Hospitals Leuven, Leuven, Belgium, 6 Computer Science, University College London, London, United Kingdom, 7 University Medical Center, Utrecht, Netherlands, 8 Developmental Psychology, Tilburg University, Tilburg, Netherlands, 9 Psychiatry, KU Leuven & University Hospitals Leuven, Leuven, Belgium

Often Neurofibromatosis type 1 (NF1) patients express hyperintensities on T2-weighted MRI brain scans. Their microstructure is still not well understood. Combining multicomponent T2 relaxation and advanced diffusion techniques (DTI, DKI, NODDI) we try to characterize these so-called "unidentified bright objects" (UBOs)

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