Abstract #1909
Altered axonal integrity of lower limb motor tracts in idiopathic normal pressure hydrocephalus: a DTI biomarker for differentiating lumbar-drainage responders from non-responders
Shih-Wei Chiang 1,2 , Cheng-Yu Chen 3,4 , Ping-Huei Tsai 3 , Hsiao-Wen Chung 1 , Chao-Ying Wang 2 , and Ming-Chung Chou 5
1
Graduate Institute of Biomedical Electronics
and Bioinformatics, National Taiwan University, Taipei,
Taiwan,
2
Department
of Radiology, Tri-Service General Hospital, National
Defense Medical Center, Taipei, Taipei, Taiwan,
3
Department
of Medical Imaging, Taipei Medical University Hospital,
Taipei Medical University, Taipei, Taiwan,
4
Institue
of Clinical Medicine, Taipei Medical University, Taipei,
Taiwan,
5
Department
of Medical Imaging and Radiological Sciences, Kaohsiung
Medical University, Kaohsiung, Taiwan
Gait disturbance in iNPH is associatedwith altered
axonal integrity in the corups callosum and lower-limb
motortracts. The degree of axonal integrity changes is
significantly increased inlumbar-drainage non-responders
than the responders. DTI may potentially beuseful in
differentiate the responders from non-responders in the
diagnosticworkup of iNPH patients who might benefit
fronm permanent ventriculo-peritonealshunting treatment.
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