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Abstract #1909

Altered axonal integrity of lower limb motor tracts in idiopathic normal pressure hydrocephalus: a DTI biomarker for differentiating lumbar-drainage responders from non-responders

Shih-Wei Chiang 1,2 , Cheng-Yu Chen 3,4 , Ping-Huei Tsai 3 , Hsiao-Wen Chung 1 , Chao-Ying Wang 2 , and Ming-Chung Chou 5

1 Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, 2 Department of Radiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taipei, Taiwan, 3 Department of Medical Imaging, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan, 4 Institue of Clinical Medicine, Taipei Medical University, Taipei, Taiwan, 5 Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan

Gait disturbance in iNPH is associatedwith altered axonal integrity in the corups callosum and lower-limb motortracts. The degree of axonal integrity changes is significantly increased inlumbar-drainage non-responders than the responders. DTI may potentially beuseful in differentiate the responders from non-responders in the diagnosticworkup of iNPH patients who might benefit fronm permanent ventriculo-peritonealshunting treatment.

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