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Abstract #1905

Atypical language lateralization in adult temporal lobe epilepsy patients: fMRI study using statistical threshold and spatial masking

Steve H Fung 1,2 , Christof Karmonik 1,2 , Mario F Dulay 1,2 , Robert G Grossman 1,2 , and Amit Verma 1,2

1 Houston Methodist Research Institute, Houston, Texas, United States, 2 Houston Methodist Hospital, Houston, Texas, United States

We investigated the effect of statistical threshold and various spatial masks on laterality index (LI) calculation in determining language lateralization in patients with temporal lobe epilepsy (TLE) evaluated using fMRI with language tasks. Majority of patients with TLE had some atypical lateralization, suggesting possible plasticity/reorganization of language function in patients with TLE.

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