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Abstract #1901

Microstructural abnormalities related to the chronification of osteoarthritic pain: a DTI study

Diane Reckziegel 1,2 , Jennifer Dixon 1,2 , and Dorothee P. Auer 1,2

1 Radiological Sciences, Division of Clinical Neurosciences, University of Nottingham, Nottingham, United Kingdom, 2 Arthritis Research UK Pain Centre, Nottingham, United Kingdom

DTI was used to investigate potential brain microstructural disruptions underlying any adaptive or predisposing changes to the networks in the brain in response to chronic knee pain due to osteoarthritis (OA). TBSS and ROI-based analysis revealed an increase in thalamic MD as pain duration increases, and a tendency for association between more neuropathic-like symptoms and MD in an area involving the insula and ACC. Our findings suggest that microstructural abnormalities in OA pain, a primary nociceptive condition, are a feature of pain chronification. They seem to develop after several years of persistent pain probably preferentially in patients with more neuropathic-like symptoms.

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