Abstract #1890
Decreased functional connectivity between the mediodorsal thalamus and default mode network in disorders of consciousness
Jianghong He 1 , Yue Cui 2 , Ming Song 2 , Yi Zhang 1 , Yuanyuan Dang 1 , Tianzi Jiang 2 , and Ruxiang Xu 1
1
Department of Neurosurgery, Beijing Army
General Hospital, Beijing 100700, China,
2
National
Laboratory of Pattern Recognition, Institute of
Automation, Chinese Academy of Sciences, Beijing 100190,
China
It is generally assumed that interactions between
thalamic nuclei and the cortex play an important role in
consciousness. Recent studies have implicated the DMN in
consciousness, which includes functional less strong
connections within the DMN in patients with DOC. The
purpose of the present study is to address this
limitation by investigating functional connectivity
between individual thalamic nuclei and the DMN in DOC
patients. 9 DOC patients and 9 age-matched healthy
controls were included in this study. In comparison to
healthy controls, DOC patients had significantly
decreased functional connectivity between the
mediodorsal thalamus and brain areas within the DMN,
including the medial prefrontal cortex and posterior
cingulate cortex/precuneus. Patients and controls did
not show differences in functional connectivity for any
thalamic nucleus other than the mediodorsal thalamus.
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