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Abstract #1890

Decreased functional connectivity between the mediodorsal thalamus and default mode network in disorders of consciousness

Jianghong He 1 , Yue Cui 2 , Ming Song 2 , Yi Zhang 1 , Yuanyuan Dang 1 , Tianzi Jiang 2 , and Ruxiang Xu 1

1 Department of Neurosurgery, Beijing Army General Hospital, Beijing 100700, China, 2 National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China

It is generally assumed that interactions between thalamic nuclei and the cortex play an important role in consciousness. Recent studies have implicated the DMN in consciousness, which includes functional less strong connections within the DMN in patients with DOC. The purpose of the present study is to address this limitation by investigating functional connectivity between individual thalamic nuclei and the DMN in DOC patients. 9 DOC patients and 9 age-matched healthy controls were included in this study. In comparison to healthy controls, DOC patients had significantly decreased functional connectivity between the mediodorsal thalamus and brain areas within the DMN, including the medial prefrontal cortex and posterior cingulate cortex/precuneus. Patients and controls did not show differences in functional connectivity for any thalamic nucleus other than the mediodorsal thalamus.

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