Abstract #1876
POSTMORTEM MRI TO GUIDE PATHOLOGICAL LOCALIZATION: INDIVIDUALIZED, 3D-PRINTED CUTTING BOXES FOR FIXED BRAINS
MARTINA ABSINTA 1,2 , GOVIND NAIR 1 , THOMAS TALBOT 3 , MASSIMO FILIPPI 2 , ABHIK RAY-CHAUDHURY 4 , CARLOS A. PARDO 5 , and DANIEL S. REICH 1
1
Translational Neuroradiology Unit, National
Institute of Neurological Disorders and Stroke (NINDS),
NIH, BETHESDA, MARYLAND, United States,
2
Neuroimaging
Research Unit, Institute of Experimental Neurology,
Division of Neuroscience, San Raffaele Scientific
Institute, Vita-Salute San Raffaele University, MILAN,
MILAN, Italy,
3
The
Laboratory of Cellular and Synaptic Neurophysiology,
NICHD, NIH, BETHESDA, MARYLAND, United States,
4
Surgical
Neurology Branch, NINDS, NIH, BETHESDA, MARYLAND, United
States,
5
Department of Neurology, Johns
Hopkins School of Medicine, BALTIMORE, MARYLAND, United
States
We developed a technology to integrate postmortem,
high-resolution MRI into the planning and execution of
the pathological analysis through the precise
localization of the target and cutting coordinates.
Compared to standard pathological sectioning, the use of
an individually rendered, 3D-printed cutting box for
formalin-fixed whole-brains can improve the speed,
quality, and accuracy of pathological localization of
small findings identi-fied on MRI and should be
applicable in a wide spectrum of neurological disorders.
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