Abstract #1871
Effects of Residual Oxygen Molecule on BOLD signal: MRI Study Using Spontaneously Breathing Brain Stroke model
Ji-Yeon Suh 1 , YoungKyu Song 1 , Jeong Kon Kim 1,2 , Young Ro Kim 3 , and Gyunggoo Cho 1
1
Magnetic Resonance Research, Korea Basic
Science Institute, Cheongwon, Chungbuk, Korea,
2
Asan
Medical Center, University of Ulsan College of Medicine,
Seoul, Korea,
3
Athinoula A. Martinos Center
for Biomedical Imaging, Massachusetts General Hospital,
Charlestown, United States
BOLD signal has been accepted to have both signal
changes, positive change by the deoxyHb decrease as well
as negative change by oxygen paramagnetism. In this
study, in order to evaluate the role of oxygen, the
relaxation times and the MRI-derived blood volumes were
measured with 21% and 100% O2 gas inhalations in
ischemic rat brains. Our results demonstrated the
excessive oxygen molecules remained in the
stroke-affected tissues by the lack of oxygen metabolism
have different actions in terms of R1 and blood volume
changes, indicating that different levels of oxygen
molecules may be related to the different changes of
BOLD signals.
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