Abstract #1855
Histogram Analysis of Saturation Time Dependent Amide Proton Transfer MRI in Brain Metastases
Jochen Keupp 1 , Yuriko Suzuki 2 , Osamu Togao 3 , and Takashi Yoshiura 3
1
Philips Research Europe, Hamburg, Germany,
2
Philips
Electronics Japan, Tokyo, Japan,
3
Department
of Clinical Radiology, Kyushu University Hospital,
Fukuoka, Japan
In recent years, amide proton transfer (APT) MRI
techniques based on endogenous contrast of exchangeable
amide protons of intra-cellular proteins and peptides
have been developed successfully and applied in initial
clinical studies for oncology and neurology
applications. For analysis of the obtained APT measures
in tumor tissue and contralateral normal appearing white
matter (NAWM), ROI averages are typically used. Because
the tumor tissue is often very heterogeneous, histogram
analyses and multi-compartment fits are applied in this
study on human brain metastases (N=5). Different
durations of the sensitizing RF saturation pulse were
chosen. With increasing duration, multiple compartments
are clearly observed while the overall tumor to NAWM
contrast is enhancing. Histogram type analysis is
strongly recommended for further investigation of APT
contrasts in tumor tissue characterization.
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