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Abstract #1838

Determination of CMRO2 changes During Hyperbaric Exposure

Damon P Cardenas 1 , Eric Muir 1 , Shiliang huang 2 , and Timothy Duong 1

1 Radiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States, 2 MRI, Research Imaging Institute, San Antonio, Texas, United States

The evaluation of CMRO2 at hyperbaric conditions is pivotal to the understanding of the physiological benefits of hyperbaric treatments. We evaluated forepaw-evoked BOLD and CBF responses simultaneously in rats under i) normobaric air, ii) normobaric oxygen, iii) hyperbaric air, and iv) hyperbaric oxygen (HBO). CMRO2 was determined using the aforementioned parameters. Despite interesting physiological response to CO2 challenges at high pressures, no significant differences were identified across conditions, implying the increased oxygen may be in excess of metabolic demand.

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