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Abstract #1836

Multimodal MRI and NIRS Measurement of CMRO2 in Grey Matter

Runze Yang 1 , R. Marc Lebel 1,2 , Qiong Zhang 1 , Filomeno Cortese 3 , Ying Wu 1 , and Jeff F. Dunn 1,4

1 Radiology, University of Calgary, Calgary, Alberta, Canada, 2 GE Healthcare, Calgary, Alberta, Canada, 3 Seaman Family MR Research Center, University of Calgary, Calgary, Alberta, Canada, 4 Experimental Imaging Center, University of Calgary, Calgary, Alberta, Canada

Abnormalities in cerebral metabolic rate for oxygen (CMRO2) are present in many neurological conditions. The current gold standard for calculating CMRO2 is with PET although MR methods are being introduced. We developed a method of quantifying CMRO2 by combining near-infrared spectroscopy and MRI. In animal experiments, we detected a change in CMRO2 induced by hypothermia. We translated this approach into human studies, where we obtained CMRO2 values similar to those of PET studies. For partial volume reasons, measuring differences between populations or over time in the same subject may be more accurate than measuring absolute values. This could be a useful method for those interested in studying brain oxidative metabolism using MRI.

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