Abstract #1836
Multimodal MRI and NIRS Measurement of CMRO2 in Grey Matter
Runze Yang 1 , R. Marc Lebel 1,2 , Qiong Zhang 1 , Filomeno Cortese 3 , Ying Wu 1 , and Jeff F. Dunn 1,4
1
Radiology, University of Calgary, Calgary,
Alberta, Canada,
2
GE
Healthcare, Calgary, Alberta, Canada,
3
Seaman
Family MR Research Center, University of Calgary,
Calgary, Alberta, Canada,
4
Experimental
Imaging Center, University of Calgary, Calgary, Alberta,
Canada
Abnormalities in cerebral metabolic rate for oxygen
(CMRO2) are present in many neurological conditions. The
current gold standard for calculating CMRO2 is with PET
although MR methods are being introduced. We developed a
method of quantifying CMRO2 by combining near-infrared
spectroscopy and MRI. In animal experiments, we detected
a change in CMRO2 induced by hypothermia. We translated
this approach into human studies, where we obtained
CMRO2 values similar to those of PET studies. For
partial volume reasons, measuring differences between
populations or over time in the same subject may be more
accurate than measuring absolute values. This could be a
useful method for those interested in studying brain
oxidative metabolism using MRI.
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