Meeting Banner
Abstract #1830

Hypercapnia effects on spontaneous low frequency fluctuations using RS-fMRI

Olga Marshall 1 , Jinsoo Uh 2 , Daniel Lurie 3 , Hanzhang Lu 2 , Michael P. Milham 4 , and Yulin Ge 1

1 1Radiology/Center for Biomedical Imaging, New York University School of Medicine, New York, NY, United States, 2 2Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Texas, United States, 3 Child Mind Institute, New York, United States, 4 Nathan S Kline Institute for Psychiatric Research, New York, United States

Carbon dioxide (CO2) is a potent vasodilator, its effect on brain cerebral blood flow and blood oxygenation level dependent (BOLD) signal changes has been well-studied. However, the influence on resting-state fMRI data is still largely unknown. In this study, we presented the results of both connectivity and amplitude changes of default mode network (DMN) under hypercapnia (mixed 5% CO2, 21% O2, and 74% N2) versus normocapnia condition at rest in healthy brains. We demonstrated that although the intrinsic correlation of the DMN at rest during CO2 remains, there is significantly reduced amplitude (measured with fractional low frequency fluctuations or fALFF) within DMN connectivity under hypercapnia.

This abstract and the presentation materials are available to members only; a login is required.

Join Here