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Abstract #1822

Investigating BOLD signal properties under targeted hyperoxic combined with progressive hypercapnia at 7T

Alex Bhogal 1 , Esben Petersen 1 , Manus J Donahue 2 , Marielle Philippens 3 , Peter Luijten 1 , Hans Hoogduin 1 , and Jeroen C.W. Siero 1

1 Radiology, University Medical Center, Utrecht, Netherlands, 2 Radiology and Radiological Sciences, Vanderbilt University, TN, United States, 3 Radiotherapy, University Medical Center, Utrecht, Netherlands

Using high spatio and temporal resolution BOLD imaging at 7T in combination with a prospective end-tidal gas targeting system (RespirAct), we examine the non-linearity of the BOLD-CVR response to increasing PaCO2 under targeted normoxia and hyperoxia in order to shed light on vascular (maximum vasodilation) and susceptibility dependent (BOLD ceiling) BOLD signal components.

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