Abstract #1819
High Resolution Mapping of Intravascular Water Molecule Lifetime in the Rhesus Macaque Brain
Ian J Tagge 1,2 , Xin Li 1 , Steven G. Kohama 3 , Christopher D Kroenke 1,4 , Yosef A Berlow 1 , Vincent B Warren 4 , Theodore R Hobbs 4 , Scott A Horrocks 4 , Nancy L Cady 4 , Jonathan Q Purnell 5 , Charles S Springer, Jr. 1 , and William D Rooney 1
1
Advanced Imaging Research Center, Oregon
Health & Science University, Portland, Oregon, United
States,
2
Biomedical
Engineering, Oregon Health & Science University,
Portland, Oregon, United States,
3
Oregon
National Primate Research Center, Hillsboro, Oregon,
United States,
4
Oregon
National Primate Research Center, Oregon, United States,
5
Department
of Endocrinology, Oregon Health & Science University,
Oregon, United States
Feasibility of measuring physiologically important
parameters such as blood volume fraction (v
b
)
and mean intravascular water molecule lifetime (
b
)
with pharmacokinetic modeling of 3D GRE DCE-MRI data is
investigated. Parametric maps are presented for healthy
adult Rhesus Macaque brain tissue. High parameter
precision (evaluated by Monte Carlo simulation) is
achieved in all tissues and parameters evaluated. 3D GRE
acquisition offers advantages over common qT
1
techniques
including faster acquisition time and greater tissue
coverage. These parameters are potentially powerful
biomarkers in the study of neurovascular diseases and
therapies.
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