Abstract #1807
Glutamate Concentration is Directly Correlated with Alpha Power Attenuation from Eyes Closed to Eyes Open in Human Occipital Lobe
Emily Mason 1 , Swati Rane 1 , Erin Hussey 1 , Subechhya Pradhan 1 , Kevin Waddell 1 , Manus J Donahue 1 , and Brandon A Ally 1
1
Vanderbilt University, Nashville, TN, United
States
One classically observed EEG signal is the attenuation
in power in the alpha bandwidth (8-12 Hz) that is seen
when a subject goes from resting with eyes closed to
resting with eyes open. The neurochemical contributions
to this phenomenon are not clearly understood, however
it is believed that the activation and resultant
desynchronization of glutamatergic pyramidal neurons are
the underlying cause. In this study, magnetic resonance
spectroscopy was used to determine the impact that
glutamate concentration in the occipital lobe may have
on an individuals alpha attenuation. As predicted,
glutamate concentration and alpha attenuation are
significantly and directly related.
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