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Abstract #1792

Pediatric ALL: Characterization of WM Damage and Associated Risk Factors

Jennifer R. Pryweller 1 , John O. Glass 1 , Xingyu Li 2 , Yimei Li 2 , and Wilburn E. Reddick 1

1 Department of Radiological Sciences, St. Jude Children's Research Hospital, Memphis, TN, United States, 2 Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, United States

MR neuroimaging studies of pediatric acute lymphoblastic leukemia (ALL), the most common form of pediatric cancer, reveal leukoencenphalopathy (LE), the most common neurotoxic side effect of treatment with high dose methotrexate. Because neurocognitive deficits resulting from LE in pediatric ALL patients can have devastating effects on quality of life, long term, the purpose of our study was to objectively assess influence and risk factors for LE in these, which was characterized by T1 and T2 intensity and relaxation rates, and the volumetric extent of abnormal white matter.

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