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Abstract #1783

Comparison between 7T T2* and 3T MTR in the in vivo human cortex.

Gabriel Mangeat 1 , Sindhuja T. Govindarajan 2 , Caterina Mainero 2 , and Julien Cohen-Adad 1

1 Biomedical institute, Ecole Polytechnique de Montreal, Montreal, Qc., Canada, 2 A.A. Martinos Center for Biomedical Imaging, MGH, Harvard Medical School, MA, United States

T2* at ultra high field MRI (7T) recently prove useful for characterising cortical myelo-architecture. However, several confounds hamper the specificity of T2*. Here, we combined T2* with magnetization transfer data (MTR) in the same cohort of healthy subjects. The goal was to assess the relationship between T2* at 7T and MTR at 3T, and show their respective sensitivity and specificity to myelin content. Data were preprocessed and then combined within a surface-based analysis framework. Average correlation between T2* and MTR was r=-0.76. Combining other metrics (T1, diffusion, T2w/T1w) within the same methodological framework could potentially bring useful insight into myelo-architecture.

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