Abstract #1780
Revisiting Two Exchangeable Proton Environments in Human Grey and White Matter Using Free and Restricted Exchangeable Proton (FREP) Imaging
Mitsue Miyazaki 1 , Cheng Ouyang 1 , Xiangzhi Zhou 1 , James B. Murdoch 1 , Tomohisa Okada 2 , Koji Fujimoto 2 , Aki Kido 2 , Yasutaka Fushimi 2 , and Kaori Togashi 2
1
Toshiba Medical Research Institute, Vernon
Hills, IL, United States,
2
Kyoto
University, Kyoto, Japan
We revisited exchange of protons between the relatively
free and restricted proton pools in macromolecule and
investigated the Z-spectra acquired over a broad and
symmetric frequency range (-30 KHz to +30 KHz). Then, a
quartet of quantitative biomarkers, i.e., proton
fractions (Ff, Fr) and spin-spin relaxation times (T2,f,
T2,r) in both free and restricted proton pools, were
mapped by fitting the measured Z-spectra to a simple
two-Lorentzian compartment model on a voxel-by-voxel
basis. The result provides a simple approach estimating
fractions and T2 values of free and restricted
exchangeable protons.
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