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Abstract #1780

Revisiting Two Exchangeable Proton Environments in Human Grey and White Matter Using Free and Restricted Exchangeable Proton (FREP) Imaging

Mitsue Miyazaki 1 , Cheng Ouyang 1 , Xiangzhi Zhou 1 , James B. Murdoch 1 , Tomohisa Okada 2 , Koji Fujimoto 2 , Aki Kido 2 , Yasutaka Fushimi 2 , and Kaori Togashi 2

1 Toshiba Medical Research Institute, Vernon Hills, IL, United States, 2 Kyoto University, Kyoto, Japan

We revisited exchange of protons between the relatively free and restricted proton pools in macromolecule and investigated the Z-spectra acquired over a broad and symmetric frequency range (-30 KHz to +30 KHz). Then, a quartet of quantitative biomarkers, i.e., proton fractions (Ff, Fr) and spin-spin relaxation times (T2,f, T2,r) in both free and restricted proton pools, were mapped by fitting the measured Z-spectra to a simple two-Lorentzian compartment model on a voxel-by-voxel basis. The result provides a simple approach estimating fractions and T2 values of free and restricted exchangeable protons.

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