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Abstract #1767

Fully automated estimation of brain volumes in post-mortem newborns and fetuses

Eliza Orasanu 1 , Andrew Melbourne 1 , M. Jorge Cardoso 1 , Marc Modat 1 , Andrew M. Taylor 2 , Sudhin Thayyil 3 , and Sebastien Ourselin 1

1 Centre of Medical Image Computing, University College London, London, United Kingdom, 2 Centre for Cardiovascular Imaging, Institute of Cardiovascular Science, University College London, London, United Kingdom, 3 University College Hospital, London, United Kingdom

Minimally invasive autopsy using post-mortem magnetic resonance imaging (MRI) can be a valid alternative to conventional autopsy in fetuses and infants. Estimation of brain weight is an integral part of autopsy, but manual segmentation of visceral organ volumes on MRI is labour intensive and unsuitable for routine clinical practice. In this paper we show that brain weight can be estimated from post-mortem brain MRI with a maximum error of 2% in fetuses and 11% in newborns using a fully automated technique. This technique can be used in clinical practice and may increase the uptake of minimally invasive autopsy.

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