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Abstract #1759

Altered structural brain networks in children with Asperger syndrome: a DTI-based connectome study

Haoxiang Jiang 1,2 , Yanni Chen 2 , Qinli Sun 1,3 , Xianjun Li 3 , Mengye Lv 3 , Yang Song 1 , and Jian Yang 1,3

1 Department of Diagnostic Radiology, The First Hospital of Medical School,Xi'an Jiaotong University, Xi'an, Shannxi, China, 2 Department of Diagnostic Radiology, Xi'an Children Hospital, Xi'an, Shannxi, China, 3 Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shannxi, China

The aim of this study is to investigate the altered structural brain networks based on diffusion tensor imaging (DTI ) in children with Asperger syndrome(AS). 22 boys with AS and 18 typically developing(TD) children with matched age and sex were collected. The results of this study indicated the topological alterations of white matter network in AS group compared to the TD group. Meanwhile, network-based statistic result displayed disrupted connected components in the right hemisphere in AS group, especially those long-range connections within the posterior part of the brain cortex and thalamus and limbic system. DTI-based brain network analysis can provide more objective estimation of brain abnormal connectivity.

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