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Abstract #1744

Predicting Myelin Content from Functional Connectivity in the Developing Brain

Jonathan O'Muircheartaigh 1,2 , Douglas C Dean III 2 , Lindsay Walker 2 , Holly Dirks 2 , Nicole Waskiewicz 2 , Irene Piryatinsky 2 , Orla Doyle 1 , and Sean Deoni 2

1 Department of Neuroimaging, King's College London, London, United Kingdom, 2 Department of Engineering, Brown University, Providence, Rhode Island, United States

Resting state fMRI is increasingly being used in developmental neuroimaging as it can be used during natural sleep in young infants and toddlers. However, the developmental trajectory of fMRI connectivity in this young age range is unclear as is its relationship with structural connectivity. Here we interrogate the typical trajectory of functional connectivity and it's relationship with a quantitative marker of myelin, the myelin water fraction, in a large cohort of 80 infants and young children aged 3 to 54 months. We indicate a linear relationship between myelination and functional connectivity.

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