Abstract #1739
Dynamics of tract level diffusion kurtosis metrics of perinatal brain white matter from 32 to 40 gestational weeks
Zihao Zhang 1,2 , Austin Ouyang 3 , Tina Jeon 3 , Rong Xue 4 , and Hao Huang 5
1
Beijing MRI Center for Brain Research,
Institute of Biophysics, Chinese Academy of Sciences,
Beijing, Beijing, China,
2
University
of Chinese Academy of Sciences, Beijing, Beijing, China,
3
Advanced
Imaging Research Center, University of Texas
Southwestern Medical Center, Dallas, Texas, United
States,
4
Beijing
MRI Center for Brain Research, Institute of Biophysics,
Chinese Academy of Sciences, Beijing, China,
5
Advanced
Imaging Research Center, University of Texas
Southwestern Medical Center, Dallas, Texas, China
From early 3rd trimester to around the birth, increased
myelination and axonal density take place in brain white
matter (WM), resulting in dramatic microstructural
changes. DKI-derived metrics, such as mean kurtosis
(MK), reflect microstructural complexity and may provide
complimentary microstructural information to that from
conventional diffusion tensor imaging (DTI). In this
study, we aimed to characterize the dynamics of the DKI
properties at the tract level and at the core of WM
tracts during the vital brain developmental stage from
32wg to 40wg, with high resolution DKI data.
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