Abstract #1718
Quantitative 3D evaluation of white matter degeneration in rat spinal cord following Dorsal Column transection using frequency shift mapping
I-Wen Evan Chen 1 , Vanessa Wiggermann 1 , Jie Liu 2 , Wolfram Tetzlaff 2,3 , Piotr Kozlowski 1,4 , and Alexander Rauscher 1,4
1
MRI Research Center, Vancouver, B.C.,
Canada,
2
International
Collaboration On Repair Discoveries, Vancouver, B.C.,
Canada,
3
Zoology,
University of British Columbia, Vancouver, B.C., Canada,
4
Radiology,
University of British Columbia, Vancouver, B.C., Canada
Recent studies of contrast in white and gray matter
(WM/GM) of the central nervous system (CNS) have
provided evidence for theories predicting phase (and
frequency shift) dependence on tissue architecture, in
the cellular and subcellular components of tissue [2-4].
Combining the well-defined (anisotropic) architecture of
the rat spinal cord dorsal column (DC) transection model
of axotomy, we study areas of neuronal damage consistent
with (expected pathology) of Wallerian and retrograde
degeneration. 3D frequency shift mapping of spinal cords
bi-directional to the injury were generated from 3D
multi-gradient echo (MGE) phase, and used to investigate
progressive degeneration over several weeks
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