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Abstract #1712

Detection of GABA, Aspartate and Glutathione in the Human Spinal Cord

Andreas Hock 1,2 , Bertram Wilm 1 , Giorgia Zandomeneghi 3 , Garyfalia Ampanozi 4 , Sabine Franckenberg 4 , Nicola De Zanche 5 , Jurek Nordmeyer-Maner 1 , Spyros S. Kollias 6 , Thomas Kraemer 4 , Michael Thali 4 , Matthias Ernst 3 , and Anke Henning 1,7

1 Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Zurich, Switzerland, 2 Department of Psychiatry, Psychotherapy and Psychosomatics Hospital of Psychiatry, University of Zurich, Zurich, Zurich, Switzerland, 3 Physical Chemistry, ETH Zurich, Zurich, Zurich, Switzerland, 4 Institute of Forensic Medicine, University of Zurich, Zurich, Zurich, Switzerland, 5 Department of Medical Physics, Cross Cancer Institute and University of Alberta, Edmonton, Alberta, Canada, 6 Institute of Neuroradiology, University Hospital of Zurich, Zurich, Zurich, Switzerland, 7 Institute for Biological Cybernetics, Max Planck Institute, Tuebingen, Baden Wrttemberg, Germany

The aim of this investigation was to expand the number of predictive markers of in vivo MR spectroscopy measurements of the human spinal cord. Therefore, data was acquired in healthy volunteers with sophisticated motion and instability correction methods as well as advanced hardware enabling the acquisition with excellent spectral quality. Aspartate, Glutathione, and GABA could be additionally identified. In addition, for the first time, the findings were cross-validated with those retrieved from a cadaveric spinal cord sample using high resolution, magic angle spinning NMR measurements enabling a qualitative indication of the presence of the additional metabolite markers found in vivo.

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