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Abstract #1710

Validation of a 2D Spinal Cord probabilistic atlas. Application to FA measurement and VBM study of the GM atrophy occurring with age

Manuel Taso 1,2 , Arnaud Le Troter 1,2 , Michal Sdika 3 , Vladimir S. Fonov 4 , Julien Cohen-Adad 5 , Maxime Guye 1,2 , Jean-Philippe Ranjeva 1,2 , and Virginie Callot 1,2

1 CRMBM UMR 7339, Aix-Marseille Universit, CNRS, Marseille, France, 2 Hopital de la Timone, ple d'Imagerie Mdicale, CEMEREM, AP-HM, Marseille, France, 3 CREATIS UMR 5220 U1044, Universit de Lyon, CNRS, INSERM, Lyon, France, 4 Montreal Neurological Institute, McGill University, Montreal, QC, Canada, 5 Institute of Biomedical Engineering, Ecole Polytechnique de Montreal, Montreal, QC, Canada

A 2D spinal cord probabilistic atlas has been recently proposed. The aim of the current work was to strengthen its construction by increasing the number of subjects involved, to validate its use for an automated white and gray matter segmentation. Investigations for automated regional FA analysis and for group studies (VBM analysis of GM distribution) were then conducted. The WM/GM atlas-based segmentation showed great potential (DICE>0.75), and further refinements that have to be brought for DTI quantification have been identified. Finally, the use of the probabilistic atlas for group studies allowed highlighting evidence of anterior GM atrophy occurring with age.

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