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Abstract #1595

Texture Analysis of Muscle 3-Point Dixon Fat-Fraction: Changes Over 1 Year

Christopher D J Sinclair 1,2 , Jasper M Morrow 1 , Arne Fischmann 3 , Michael G Hanna 1 , Mary M Reilly 1 , Tarek A Yousry 1,2 , and John S Thornton 1,2

1 MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, London, United Kingdom, 2 Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom, 3 University of Basel Hospital, Basel, Switzerland

Fat-water quantification is a promising method for sensitively measuring changes in muscle in upcoming clinical trials in neuromuscular diseases. In this work we applied texture analysis to 3-point Dixon fat fraction maps to assess fat-infiltration in the hamstring muscles in 17 patients with the representative condition inclusion body myositis, measured twice at a 1 year interval. Mean fat-fraction, contrast, homogeneity run length image texture measures all changed significantly over 1 year. There were no equivalent texture parameter changes in a healthy volunteer group over this period, demonstrating the promise of muscle fat-fraction texture analysis for measuring longitudinal fat-infiltration in neuromuscular conditions.

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