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Abstract #1588

EPI distortion correction for quantitative imaging of the mouse brain at ultrahigh magnetic field

Xuan Vinh To 1 , Xin Hong 1 , Irvin Teh 2 , Jian Rui Soh 1 , and Kai-Hsiang Chuang 1

1 Lab of Molucular Imaging, Singapore Bioimaging Consortium, Singapore, Singapore, Singapore, 2 A*STAR - NUS Clinical Imaging Research Centre, Singapore, Singapore

Echo Planar Imaging (EPI) is an ultrafast acquisition technique widely used in fMRI, diffusion imaging and perfusion imaging but suffers from geometric and intensity distortions, especially in ultrahigh field strength used in small animal imaging. In this study we compared several distortion correction methods. We found using a pair of reference EPI images acquired with opposite phase encoding directions to calculate an unwrapping field provides the most accurate, robust and efficient distortion correction for the mouse brain.

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