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Abstract #1525

Anatomically weighted 2 nd order Total Variation reconstruction of 23 Na MRI using 1 H prior information

Christine Gnahm 1 , Nicolas G.R. Behl 1 , Armin Biller 2 , Peter Bachert 1 , and Armin M. Nagel 1

1 Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2 Department of Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany

23 Na MRI is still hampered by low signal-to-noise ratio (SNR) and long acquisition times. We present an iterative reconstruction method using a priori information from high-SNR high-resolution 1 H MRI through anatomically weighted 2 nd order Total Variation regularization (AnaWeTV). By anatomical weighting, intensity variations in the 23 Na image are promoted at positions with high confidence of tissue boundaries. In simulated brain images, it is shown that the total sodium concentration in small lesions that are known a priori can be determined more precisely. Furthermore, we find a 2.2 fold SNR increase over gridding in 23 Na MRI of a MS patient.

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