Abstract #1523
Partial Volume Correction for 23 Na MRI of Human Brain
Sebastian C. Niesporek 1 , Stefan H. Hoffmann 1 , Moritz C. Berger 1 , and Armin M. Nagel 1
1
Medical Physics in Radiology, German Cancer
Research Center (DKFZ), Heidelberg, Germany
The tissue sodium (
23
Na) concentration is of
great interest in biomedical research. However the
23
Na
nucleus has a low MR sensitivity and fast relaxation
times which requires larger voxel sizes in
23
Na
MRI. Thus, partial volume effects reduce the accuracy of
concentration measurements. In this work, a partial
volume correction method was transferred to
23
Na
MRI, optimized and tested in phantom measurements and
simulations as wells as in
23
Na
MRI of the human brain. The study showed good correction
capability for phantom and
in-vivo
data.
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