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Abstract #1492

On the application of simultaneous dual contrast weighting using double echo 2in1-RARE in healthy subjects and multiple sclerosis patients

Katharina Fuchs 1 , Fabian Hezel 1 , Sabrina Klix 1 , Ralf Mekle 2 , Jens Wuerfel 3,4 , and Thoralf Niendorf 1,5

1 Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany, 2 Medical Metrology, Physikalisch Technische Bundesanstalt, Berlin, Germany, 3 Institute of Neuroradiology, University Medicine Goettingen, Germany, 4 NeuroCure Clinical Research Center, Charit - University Medicine Berlin, Germany, 5 Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charit Medical Faculty and the Max-Delbrueck Center, Berlin, Germany

2in1-RARE is a RARE variant which is simultaneously sensitive to T 2 * and proton density contrast. This is achieved by strictly separating spin echo and stimulated echo magnetization within a RARE echo train. The performance of 2in1-RARE is elucidated using point spread function assessment. 2in1-RARE traits for T 2 * mapping are validated against conventional mulit-echo gradient echo acquisitions. The applicability of dual contrast weighted double echo 2in1-RARE is demonstrated for brain imaging using susceptibility weighted imaging, T 2 * mapping and proton density weighted imaging in healthy subjects and multiple sclerosis patients.

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