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Abstract #1437

Detection of hepatic glycogen by 1D ISIS localized 13 C MRS at 7T.

Martin Krssak 1,2 , Martin Gajdosik 2 , Ladislav Valkovic 2 , Wolfgang Bogner 2 , Michael Krebs 1 , Anton Luger 1 , Siegfried Trattnig 2 , and Marek Chmelik 2

1 Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, 1090, Austria, 2 High Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Wien, Austria

The aim of this study was to introduce and test the 13 C MRS localization scheme suitable for the measurement of hepatic glycogen at 7T in short acquisition time. One dimensional slice selective version of recently introduced fully adiabatic extended ISIS sequence was proposed and tested on phantom and in vivo on healthy volunteers. 1D ISIS scheme applied at 7T presented optimal localization performance and sufficient signal to noise of natural abundance 1- 13 C hepatic glycogen doublet in relatively short acquisition times (416).

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