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Abstract #1405

Wireless MR active marker based PET motion correction in simultaneous brain MR-PET

Chuan Huang 1 , Jerome L Ackerman 2 , Yoann Petibon 1 , Marc D Normandin 1 , Georges El Fakhri 1 , and Jinsong Ouyang 1

1 Center for Advanced Medical Imaging Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 2 Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

Recently, wireless active markers have been used in head motion tracking/correction in brain MRI due to its improved patient safety, ease-of-use and simpler manufacturing. Head motion is even more a problem in brain PET since dynamic brain PET can last more than an hour. Furthermore, anesthesia is often used to keep animals still during brain PET acquisitions, but many studies showed that anesthesia can also perturb the neurological process under study. Simultaneous MR-PET is a novel hybrid modality generated substantial interest in recent years. Complementary information of the brain from PET and MR can be simultaneously obtained. This new modality also opens the possibility to use MR active marker derived motion information for PET motion correction. In this work, we demonstrate in phantom and non-human primate studies the use of wireless active markers to track head motion and incorporating the measure motion information in the list-mode PET reconstruction to obtain PET images without motion artifacts in simultaneous MR-PET.

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