Meeting Banner
Abstract #1401

Combining MRI with PET for partial volume correction improves image-derived input functions in mice

Eleanor Evans 1 , David Izquierdo Garcia 2 , Guido Buonincontri 1 , Carmen Methner 3 , Rob C Hawkes 1 , Thomas Kreig 3 , T. Adrian Carpenter 1 , and Stephen J Sawiak 1,4

1 Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom, 2 Athinoula A. Martinos Centre for Biomedical Imaging, Harvard University, Massachusetts, United States, 3 Department of Medicine, University of Cambridge, Cambridge, United Kingdom, 4 Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, United Kingdom

Kinetic modelling in Positron Emission Tomography (PET) allows metabolic measures to be obtained, but requires the tracer arterial input function (AIF). Blood sampling to acquire the AIF is prohibitive in mice due to low blood volumes. Image-derived AIFs are therefore preferred, although their extraction from blood vessels is hampered by low spatial resolution (~1.5-2mm). We found that using an AIF extraction method which employed partial volume correction (PVC) in the mouse heart was crucial for deriving accurate AIFs and gave best results when ROIs were based on MRI data rather than PET data.

This abstract and the presentation materials are available to members only; a login is required.

Join Here