Abstract #1351
Ladder-design volume coil with good uniformity and signal to noise for hyperpolarised 13 C investigations of animals on a 3T clinical system
Deborah K. Hill 1,2 , Craig Cummings 1 , Jessica K. R. Boult 1 , Matthew R. Orton 1 , Yuen-Li Chung 1 , Thomas R. Eykyn 1,3 , Martin O. Leach 1 , David J. Collins 1 , and Rafal Panek 1
1
CR-UK and EPSRC Cancer Imaging Centre, The
Institute of Cancer Research and Royal Marsden NHS
Trust, Sutton, Surrey, United Kingdom,
2
Department
of Circulation and Medical Imaging, NTNU, Trondheim,
Sr-Trndelag, Norway,
3
St
Thomas Hospital, Kings College London, London, United
Kingdom
Signal enhancement by Dynamic Nuclear Polarisation of
13
C
makes it possible to conduct real-time measurements of
low concentration metabolites
in
vivo
. Implementation of preclinical work on clinical
systems for DNP studies is attractive, but severely
limited by surface coils when moving from subcutaneous
to orthotopic and genetically modified models. We
describe and characterise a custom-made
13
C
volume ladder-design coil; the coil shows superior SNR
and B
1
homogeneity
in both phantom studies and
in
vivo
in
mice when compared to a typical surface coil.
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