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Abstract #1298

Development of an MRI method for awake mouse imaging using soft immobilization and a fast MR acquisition procedure

Shunsuke Kusanagi 1 , Kazunari Kimura 1 , Makoto Hirakane 1 , Shigeto Iwamoto 1 , Rikita Araki 2 , Sosuke Yoshinaga 1 , and Hiroaki Terasawa 1

1 Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan, 2 Bruker Biospin K.K., Yokohama, Kanagawa, Japan

Mouse MRI studies facilitate the elucidation of the pathogenic mechanisms underlying various diseases and the appropriate medical treatments, due to the remarkable advances in mouse genetic technology. It is difficult to acquire accurate MR images when an imaging target moves in the scanner, and thus treatment with anesthesia and fixing apparatuses are usually required. However, the brain activation profiles were reportedly affected by anesthesia. To exclude the unfavorable anesthetic effects, we successfully developed an easy-to-operate method for awake mouse brain imaging, which uses softer immobilization with clothes for mice and a fast MR acquisition procedure, without surgery and training.

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