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Abstract #1263

Changes in Muscle Mitochondrial Energetics in Vivo and Physical Fitness in Operable Rectal Cancer Patients Following Neoadjuvant Chemoradiotherapy An Observational Pilot Study

Malcolm A West 1 , Lisa Loughney 2 , Michael PW Grocott 3 , Sandy Jack 3 , and Graham J Kemp 1

1 Magnetic Resonance and Image Analysis Research Centre, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, Merseyside, United Kingdom, 2 Critical Care Research Area, NIHR Respiratory BRU, University Hospital Southampton, Southampton, Hampshire, United Kingdom, 3 Integrative Physiology and Critical Illness Group, Faculty of Medicine, University of Southampton, Hampshire, United Kingdom

This prospective study of 12 locally advanced rectal cancer patients aims to investigate the effects of standardised neoadjuvant chemoradiotherapy (NACRT) on objectively measured mitochondrial energetics and physical fitness using 31-phosphorus magnetic resonance spectroscopy (31P MRS) and cardiopulmonary exercise testing (CPET). A significant reduction in oxygen uptake at estimated lactate threshold, oxygen uptake at Peak exercise (, and a parallel decrease in post-exercise phosphocreatine (PCr) recovery rate constant (kPCr min-1 suggests that mitochondrial mechanisms are important in the loss of fitness induced by NACRT.

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