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Abstract #1250

3D Model for MR Image Contrast in the Annulus Fibrosus of the Intervertebral Disc

Alexander C. Wright 1 , Edward J. Vresilovic 2 , and Dawn M. Ellliott 3

1 Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2 Department of Orthopaedics and Rehabilitation, Penn State University, Hershey, PA, United States, 3 Department of Biomedical Engineering, University of Delaware, Newark, DE, United States

The purpose of this study is to provide a theoretical model for the visibility (image contrast) of collagen lamellae in the annulus fibrosus as seen in MRI. The model is based on the assumption of a dipolar term in the T2 relaxation mechanism of water protons and that the observed anisotropic modulation of signal intensity reflects the underlying microstructure of collagen fibers.

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