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Abstract #1244

In vivo magnetic resonance elastography of the human intervertebral disk: Preliminary results

Kaspar Josche Streitberger 1,2 , Jing Guo 1 , Gerd Diederichs 1 , Sebastian Hirsch 1 , Andreas Fehlner 1 , Jrgen Braun 3 , and Ingolf Sack 1

1 Department of Radiology, Charit - Universittsmedizin Berlin, Berlin, Berlin, Germany, 2 Department of Neurology, Charit - Universittsmedizin Berlin, Berlin, Berlin, Germany, 3 Medical Informatics, Charit - Universittsmedizin Berlin, Berlin, Berlin, Germany

The noninvasive detection and quantification of the human intervertebral disk by MR elastography (MRE) could be beneficial for the diagnosis of chronic disk degeneration. This study presents the first in vivo measurement of viscoelastic constants of the human intervertebral disc by MRE. Multifrequency MRE and multifrequency wave field inversion was applied to 15 healthy volunteers one of whom was measured 7 times on 7 different days. The magnitude of the complex shear modulus measured in the nucleus pulposus (mean value 4.34 1.2 kPa) shows a good reproducibility and correlates with the MRI morphology based Pfirrmann score.

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