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Abstract #1237

Quantitative skeletal muscle NMR imaging of juvenile dermatomyositis patients

Pierre G Carlier 1 , Noura Azzabou 1 , Paulo Loureiro de Sousa 1 , Benot Florkin 2 , Emmanuel Deprez 3 , Norma B Romero 4 , Sverine Denis 5 , Valrie Decostre 6 , and Laurent Servais 7

1 AIM-CEA Institut de Myologie, Laboratoire RMN, Paris, France, 2 CHR La Citadelle, Service de Pdiatrie, Lige, Belgium, 3 CHU de Lige, Service anatomie et cytologie pathologiques, Lige, Belgium, 4 AIM, Institut de Myologie, Laboratoire d'histopathologie, Paris, France, 5 Centre de rfrence des maladies neuromusculaires, CHR La Citadelle, Lige, Belgium, 6 AIM, Institut de Myologie, Laboratoire de physiologie et d'valuation neuromusculaire, Paris, France, 7 AIM, Service Essais Cliniques et Bases de Donnes, Paris, France

The existence of oedematous/inflammatory/necrotic lesions is subjectively appreciated on T2-weighted images. Because it relies on identification of hyperintensities between and within muscles, the interpretation risk with T2-weighted images is to miss global, homogenous increases in T2. We demonstrate here this concern to be more than theoretical. Three patients aged 6, 7 and 12 were referred for suspicion of dermatomyositis. Standard T2w imaging was normal or subnormal. Quantitative T2 maps showed that muscle water T2s were abnormally elevated in the limb girdles and lower limbs. Quantitative T2 mapping can be required to detect unambiguously muscle lesions as here in juvenile dermatomyositis.

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