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Abstract #1231

Using 31 P-MRS to Explore the Effects of Iron Deficiency on Murine Skeletal Muscle Function and Metabolism During Exercise

M. Kate Curtis 1 , Lowri E. Cochlin 2 , Mark A. Cole 3 , David P. O'Neill 1 , Michael S. Dodd 1,4 , Damian J. Tyler 1,4 , Kieran Clarke 1 , and Peter A. Robbins 1

1 Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom, 2 Department of Physiology, Anatomy and Genetics, PulseTeq Ltd, Oxford, United Kingdom, 3 Department of Life Sciences, University of Nottingham Medical School, Nottingham, United Kingdom, 4 Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom

Physical work or exercise capacity has been widely reported as being impaired by iron deficiency in both human and animal studies. The aim of this project was to develop a technique that allows for the simultaneous assessment of force production, fatigue resistance and metabolic function of murine gastrocnemius muscle during exercise. To address this, a method of in vivo gastrocnemius muscle stimulation was successfully established, which allows the simultaneous measurement of energetics, by 31P MRS, and induced force production in a murine model of altered iron status.

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