Abstract #1221
Evaluation of vastus lateralis muscle fat fraction measured by two-point Dixon water-fat Imaging and 1H-MRS
Sunil K. Valaparla 1,2 , Erika M. Ripley 2 , Goldie R. E. Boone 2 , Timothy Q. Duong 1 , and Geoffrey D. Clarke 1,2
1
Research Imaging Institute, University of
Texas Health Science Center at San Antonio, San Antonio,
Texas, United States,
2
Radiology,
University of Texas Health Science Center at San
Antonio, San Antonio, Texas, United States
1H-MRS and two-point Dixon MRI provide reliable fat
fraction, correlating well with tissue biopsies. This
study compared fat fraction in human vastus lateralis
(VL) using Dixon MRI and long TE 1H-MRS at 3T. Fat
fraction exhibited considerable inter-individual
variability for 1H-MRS FF (%) = 3.61 2.25 (range: 1.34
7.23) and Dixon MRI FF (%) = 3.11 1.17 (range: 1.77
5.60). Linear regression analysis showed good
correlation (r = 0.8746) between FF (%) from two
methods. These methods can provide insight on muscular
fat interference with insulin signaling in diabetes and
give a reliable basis for longitudinal clinical studies.
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