Abstract #1215
The Origin that Darkens the Deep Region of Articular Cartilage in MRI when Loaded at the Magic Angle
Yang Xia 1 and Nian Wang 1
1
Physics and Center for Biomedical Research,
Oakland University, Rochester, Michigan, United States
To investigate the molecular origin that darkens the
deep-region of articular cartilage when the tissue is
compressed and oriented at the magic angle, T2 and T1ρ
experiments were used to study native and degraded
cartilage. The glycosaminoglycan (GAG) concentrations in
the specimens were quantified by both sodium ICP-OES and
T1-Gd methods. The GAG concentration was found to play
the key role in the formation of this low-intensity
layer in the deep-region of the compressed cartilage. A
schematic model has been formulated to explain the
structural differences in the deformation of the
collagen matrix between native and degraded tissues.
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