Abstract #1213
Evaluation of the BOLD Signal in Response to CO2 or O2 in JIA Patients at 3T: A Pilot Study
Afsaneh Amirabadi 1 , Adrian Crawley 2 , Carina Man 1 , Tammy Rayner 1 , Ruth Weiss 1 , Joseph Fisher 2,3 , and Andrea Doria 1,4
1
The Hospital for Sick Children, Toronto, ON,
Canada,
2
The
University Health Network, ON, Canada,
3
Thornhill
Research Inc., ON, Canada,
4
University
of Toronto, ON, Canada
Juvenile idiopathic arthritis is the most frequent
chronic rheumatologic disease of childhood. Early
diagnosis may improve therapy efficacy and decrease
adverse outcomes. In the acute arthritis increased
metabolic demand and the inadequate oxygen delivery
through the inflamed synovium result in hypoxia. In this
study 3T BOLD MRI was used to obtain functional
information of the periarticular tissue reactivity in
response to local hypoxia which is directly relevant to
the pathogenesis of arthritis. End-tidal gas
concentrations were manipulated using a model-based
prospective targeting device during BOLD MRI. The
results showed non statistically significant percent
signal change difference between inflammatory and
healthy tissue.
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