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Abstract #1213

Evaluation of the BOLD Signal in Response to CO2 or O2 in JIA Patients at 3T: A Pilot Study

Afsaneh Amirabadi 1 , Adrian Crawley 2 , Carina Man 1 , Tammy Rayner 1 , Ruth Weiss 1 , Joseph Fisher 2,3 , and Andrea Doria 1,4

1 The Hospital for Sick Children, Toronto, ON, Canada, 2 The University Health Network, ON, Canada, 3 Thornhill Research Inc., ON, Canada, 4 University of Toronto, ON, Canada

Juvenile idiopathic arthritis is the most frequent chronic rheumatologic disease of childhood. Early diagnosis may improve therapy efficacy and decrease adverse outcomes. In the acute arthritis increased metabolic demand and the inadequate oxygen delivery through the inflamed synovium result in hypoxia. In this study 3T BOLD MRI was used to obtain functional information of the periarticular tissue reactivity in response to local hypoxia which is directly relevant to the pathogenesis of arthritis. End-tidal gas concentrations were manipulated using a model-based prospective targeting device during BOLD MRI. The results showed non statistically significant percent signal change difference between inflammatory and healthy tissue.

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