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Abstract #1211

Multiparametric therapy study of the goat cartilage after inducing Osteoarthritis

Joachim Hermann Xaver Schrauth 1,2 , Gunthard Lykowsky 1,2 , Daniel Weber 1 , Jakob Kreutner 1,2 , Kathrin Hemberger 1,2 , Lars Rackwitz 3 , Ulrich Nth 3 , Peter Jakob 1,2 , and Daniel Haddad 1

1 Molecular & Cellular MRI, MRB Research Center for Magnetic Resonance Bavaria, Wuerzburg, Bavaria, Germany, 2 Experimental Physics 5 (Biophysics), University Wuerzburg, Wuerzburg, Bavaria, Germany, 3 Knig-Ludwig-Haus, Orthopdische Universittsklinik Wrzburg, Wuerzburg, Bavaria, Germany

The aim of this study was to compare Sodium, T1ρ and dGEMRIC measurements for the characterization of the goat cartilage after inducing Osteoarthritis in a control and cell based treated group. The results of all methods show expected behavior over the course of 16 weeks after the defect, though T1ρ seems to be most sensitive to early changes in the cartilage. Moreover we found a very strong correlation between the both known dGEMRIC indices and moderate correlations between Sodium & dGEMRIC(1), dGEMRIC(1) & T1ρ and dGEMRIC(2) & T1ρ.

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