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Abstract #1183

T2* value change of Hoffa s fat pad with histologic correlation in a rat model of anterior cruciate ligament transection

Chao-Ying Wang 1 , Ping-Huei Tsai 2,3 , Shih-Wei Chiang 1,4 , Yi-Chih Hsu 1 , Herng-Sheng Lee 5 , Yue-Cune Chang 6 , Ming-Chung Chou 7 , Ming-Huang Lin 8 , Chien-Yuan Lin 8 , Hsiao-Wen Chung 4 , and Guo-Shu Huang 1

1 Department of Radiology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan, 2 Imaging Research Center, Taipei Medical University, Taipei, Taiwan, 3 Department of Medical imaging, Taipei Medical University, Taipei, Taiwan, 4 Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, 5 Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, 6 Department of Mathematics, Tamkang University, Taipei, Taiwan, 7 Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan, 8 Institute of Biomedical Sciences, Academic Sinica, Taipei, Taiwan

In this study we use MR T2* value to compare local changes in signal intensity over time in Hoffas fat pad in anterior cruciate ligament transection (ACLX) rats. We have applied these techniques to investigate at different time points including week 0, 4, 13, 18 in three groups (control, ACLX-shame and ACLX) after surgery. After MR imaging at week 18, we scarified the rat and undergone histological analysis. We conclude that in our study of Hoffas fat pad, MR T2* measurement can be an useful biomarker to provide early physiological information in knee instability disease.

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