Abstract #1183
T2* value change of Hoffa s fat pad with histologic correlation in a rat model of anterior cruciate ligament transection
Chao-Ying Wang 1 , Ping-Huei Tsai 2,3 , Shih-Wei Chiang 1,4 , Yi-Chih Hsu 1 , Herng-Sheng Lee 5 , Yue-Cune Chang 6 , Ming-Chung Chou 7 , Ming-Huang Lin 8 , Chien-Yuan Lin 8 , Hsiao-Wen Chung 4 , and Guo-Shu Huang 1
1
Department of Radiology, Tri-Service General
Hospital and National Defense Medical Center, Taipei,
Taiwan,
2
Imaging
Research Center, Taipei Medical University, Taipei,
Taiwan,
3
Department
of Medical imaging, Taipei Medical University, Taipei,
Taiwan,
4
Graduate
Institute of Biomedical Electronics and Bioinformatics,
National Taiwan University, Taipei, Taiwan,
5
Department
of Pathology, Tri-Service General Hospital, National
Defense Medical Center, Taipei, Taiwan,
6
Department
of Mathematics, Tamkang University, Taipei, Taiwan,
7
Department
of Medical Imaging and Radiological Sciences, Kaohsiung
Medical University, Kaohsiung, Taiwan,
8
Institute
of Biomedical Sciences, Academic Sinica, Taipei, Taiwan
In this study we use MR T2* value to compare local
changes in signal intensity over time in Hoffas fat
pad in anterior cruciate ligament transection (ACLX)
rats. We have applied these techniques to investigate at
different time points including week 0, 4, 13, 18 in
three groups (control, ACLX-shame and ACLX) after
surgery. After MR imaging at week 18, we scarified the
rat and undergone histological analysis. We conclude
that in our study of Hoffas fat pad, MR T2*
measurement can be an useful biomarker to provide early
physiological information in knee instability disease.
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