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Abstract #1178

Rapid increase of marrow fat content and decrease of marrow perfusion in females underwent bilateral oophorectomy: An magnetic resonance based longitudinal study of lumbar vertebra

Yi-Xiang Wang 1 , David KW Yeung 1 , Min Deng 1 , Jing Yuan 1 , and James F Griffith 1

1 Dept Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong

Lumbar spine bone mineral density (BMD) with quantitative CT, marrow fat fraction (FF) and marrow perfusion using MRS and DCE MRI at the L3 vertebra in 6 females underwent hysterectomy and bilateral salpingo-oophorectomy were performed. Reduced BMD, increased marrow FF, and reduced marrow perfusion occurred in synchrony. There was a sharp decrease of 12.57.2% for BMD (n=6), a sharp increase of 92.246.3% (n=6) for FF, a sharp decrease of 23.63.9% for maximum enhancement (n=5), and of 45.47.7% for enhancement slope (n=5) during the initial 3 months post surgery. These changes occurred at a slower rate during the later follow-up period.

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