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Abstract #1176

Co-registration of Synchrotron Radiation-microCT and micro-MRI images: a new method for the complete characterization of newly-formed bone

Allegra Conti 1 , Raffaele Sinibaldi 1 , Silvia Capuani 2 , Tonino Traini 3 , Gian Luca Romani 1,4 , and Stefania Della Penna 1,4

1 Department of Neuroscience and Imaging, University of Chieti, Chieti, CH, Italy, 2 Department of Physics, Sapienza University of Rome, Rome, RM, Italy, 3 Department of Stomatology and Biotechnologies, University of Chieti, Chieti, CH, Italy, 4 Institute of Advanced Biomedical Technologies, University of Chieti, Chieti, CH, Italy

The use of biomaterials scaffolds for bone regeneration/augmentation represents one of the most used strategies in dentistry to support prosthetic restorations. Often implant failure can be associated to the trabecular bone quality of the jaw. Here we present a new method based on the co-registration of images of scaffold collected with the X-ray Synchtron Radiation-microCT and micro-MRI, that permit to obtain a complete and 3D characterization of scaffolds, distinguishing unambiguously different degrees of bone mineralization, multinucleate cells and blood vessels inside the bone marrow. Until now this was possible only with an histological, and so bidimensional, evaluation of the samples.

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