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Abstract #1169

Investigation of Relationship between Free-Water T1 and Age in Human Cortical Bone Employing Short-TE 1H-MRI at 1.5T

Atena Akbari 1,2 , Shahrokh Abbasi Rad 1,2 , Mohsen Shojaee Moghaddam 3 , and Hamidreza Saligheh Rad 1,2

1 Medical Physics and Biomedical Engineering Department, Tehran University of Medical Sciences, Tehran, Tehran, Iran, 2 Quantitative MR Imaging and Spectroscopy Group, Research Center for Molecular and Cellular Imaging, Tehran, Tehran, Iran, 3 Imaging Center, Payambaran Hospital, Tehran, Tehran, Iran

Larger pores in human cortical bone (>30 m) have essential role in its mechanical competence, suggesting to quantify such proton pools as a reliable measure of cortical bone porosity and thus, cortical bone quality. Signal from such pores can be reliably captured using short echo time (STE) pulse sequence with echo-time in range of 0.5-1msec. Furthermore, it is well-known that cortical bone T1-relaxivity is a function of its geometrical characteristics, suggesting subject-dependent cortical bone free water increasing with age. In this work, we investigated relationship between STE-based cortical bone T1-values and age, studies in a group of healthy volunteers at 1.5T.

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